http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5849873-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2658d45a8e9c71b9598e2bf83242bab3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2400-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-523 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-241 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52 |
| filingDate | 1995-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c60902f7db271091490e9bc4bc2e11c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64910da0837e7bcce1f8e5fc81f7b8e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6b95b39b8b207c53b6d14e259019422 |
| publicationDate | 1998-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5849873-A |
| titleOfInvention | Macrophage-derived inflammatory mediator (MIP-1 α and MIP-1 β) |
| abstract | An inflammatory cytokine is disclosed which has been isolated from cells that have been incubated with a stimulator material. The inflammatory cytokine comprises a protein that is capable of binding to heparin, inducing localized inflammation characterized by polymorphonuclear cell infiltration when administered subcutaneously and inducing in vitro polymorphonuclear cell chemokinesis, while lacking the ability to suppress the activity of the anabolic enzyme lipoprotein lipase, cause the cytotoxicity of cachectin/TNF-sensitive cells, stimulate the blastogenesis of endotoxin-resistant C3H/HeJ thymocytes, or induce the production of cachectin/TNF by primary thioglycollate-elicited mouse macrophage cells. A particular inflammatory cytokine MIP-1 has been isolated and has been found to comprise a peptide doublet of similar molecular weights of about 8,000 daltons, and to show a pI of about 4.6. The doublet has been resolved into its component peptides, MIP-1 alpha and MIP-1 beta for which distinct cDNA's have been cloned and sequenced. Diagnostic and therapeutic utilities are proposed, and testing procedures, materials in kit form and pharmaceutical compositions are likewise set forth. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7435799-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004131612-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7101978-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006269549-A1 |
| priorityDate | 1981-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 84.