| abstract |
This invention provides compounds of formula I having the structure <IMAGE> 1 wherein R is (CH2)nCOOR4; R1 is hydrogen, alkyl, alkenyl, alkynyl, alkylcycloalkyl, and alkoxyalkyl; R4 is hydrogen or alkyl; R5, R6, R7, and R8 are each, independently, hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, arylalkoxy, fluoroalkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, cyano, nitro, -SCF3, -COR3, alkanoyloxy, hydroxy, trifluoromethyl, amino, alkylamino, dialkylamino, alkylamido, or alkylsulfonamido; wherein at least one of R5, R6, R7, or R8 is cyano; R3 is alkyl, hydroxy, alkoxy, amino, alkylamino; X is -O- or -C-; and n=1-4 or a pharmaceutically acceptable salt thereof, which are useful in the treatment of arthritic disorders, colorectal cancer, and Alzheimer's disease. |