| abstract |
The present invention provides certain substituted 1,2,3,4-tetrahydrocyclopenta [b] indole-3 of formula (Ia) that exhibit useful pharmacological properties, eg, properties as agonists of the S1P1 receptor. -Yl) It relates to acetic acid derivatives and pharmaceutically acceptable salts thereof. Also according to the present invention, a pharmaceutical composition comprising a compound of the present invention, and an S1P1 receptor related disorder such as psoriasis, rheumatoid arthritis, Crohn's disease, graft rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis Methods of using the compounds and compositions of the invention in the treatment of type I diabetes, acne, microbial infections or diseases and viral infections or diseases are provided. |