| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba045776bcd32d32e3100da8dfce4e28 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4476
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-5537
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4465 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-553
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 |
| filingDate |
1996-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1998-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a4ac0f58d5ac1e7f83e05f27c6de005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ab0536d088b298ce4b0d56a7d77ac35 |
| publicationDate |
1998-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5807688-A |
| titleOfInvention |
Catalytic antibodies for carbamate activation by a non-spontaneous reaction mechanism |
| abstract |
Catalytic antibodies capable of catalysing activation of a carbamate (--O--CO--NH--) containing prodrug suitable for Antibody Directed Abzyme Prodrug Therapy (ADAPT) by catalysing breakdown of the prodrug at the carbamate position by a non-spontaneous reaction mechanism. The non-spontaneous reaction preferably has a B Ac 2 mechanism and the prodrug is a preferably a nitrogen mustard aryl carbamate. The invention also includes relevant immunogens, screens for catalytic activity using short transition state analogues and ADAPT systems. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8753611-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8765100-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8802130-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005142198-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010247546-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8728441-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004029108-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8685644-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004053424-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011212034-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8092832-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8119158-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8298577-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005171065-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011070169-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011071181-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011073518-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6452044-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7670617-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6852750-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005031677-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003083505-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005239132-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7858121-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7862832-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7862833-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005169989-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005163838-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7141385-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005037072-A1 |
| priorityDate |
1995-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |