| abstract |
Peptide derivatives usable as zinc endopeptidase 24-15 inhibitors. These peptide derivatives have the following amino acid sequence:-Phe psi (PO2CH2)-(L,D)Xaa'-Yaa'-Zaa'-in which psi (PO2CH2) indicates that the peptide bond (CONH) has been replaced by the phosphine bond (PO2CH2), Xaa' and Zaa', which can be the same or different, in each case represent a natural amino acid or an amino pseudo-acid and Yaa' represents Arg or Lys. As examples of such derivatives, reference can be made to those of formula:Z-(L,D)Phe psi (PO2CH2)-(L,D)-Gly-Arg-MetOHZ-(L,D)Phe psi (PO2CH2)-(L,D)-Ala-Arg-MetOHZ-(L,D)Phe psi (PO2CH2)-(L,D)-Ala-Arg-PheOHwith Z representing the benzyloxycarbonyl group. |