| abstract |
The invention relates to novel peptide derivatives usable as inhibitors of bacterial collagenases. These derivatives comply with the formula: <IMAGE> (I) in which R1 is a hydrogen atom, a blocking group or a radical derived from an amino acid or a peptide optionally protected by a blocking group, R2 is the side chain of an alpha -amino acid, R3 is H, a metal, an alkyl or benzyl group, R4 is the derivative of proline, hydroxyproline, thiazolidine or dehydroproline, R5 is H or an alkyl, R6 is the side of an amino acid and R7 is OR8 with R8 being H, a metal, alkyl or benzyl, or in which R1 and R7 together form a divalent radical derived from an amino acid or a peptide. The derivatives in which R3 is a metal or hydrogen are usable as inhibitors of bacterial collagenases. |