| abstract |
PCT No. PCT/JP94/01047 Sec. 371 Date Apr. 27, 1995 Sec. 102(e) Date Apr. 27, 1995 PCT Filed Jun. 28, 1995 PCT Pub. No. WO95/01178 PCT Pub. Date Jan. 12, 1995There are provided novel antitussive agents different from existing antitussive agents or those under development. Antitussive agents containing morphinan derivatives represented by compound 6:id-addition salts thereof and those derivatives or their salts as effective components. The antitussive agents according to the present invention have strong antitussive effects as highly selective kappa -opioid agonists, and may thus be applied as useful antitussive agents in the prophylaxis and treatment of coughing in a patient in need thereof. |