Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_60da379fb33c192ef77f86a60c5ac029 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1055 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
filingDate |
1995-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
1998-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edea79e3bf573fa94ad338aef7013353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e5dd6dfe25750a57d594aeeb5562c43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3005dbe0ffb99f0d5a4634f8b6184521 |
publicationDate |
1998-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-5733726-A |
titleOfInvention |
Cytotoxicity-based genetic selection system (TOXSEL) |
abstract |
The invention provides a cytotoxicity-based genetic selection (TOXSEL) method and related testing kit for the identification and positive selection of molecules or mutations that are capable of disrupting a specific protein--protein interaction. The invention enables positive selection of molecules disruptive of specific protein--protein interactions by virtue of the presence in the TOXSEL system of a toxin reporter gene. A disrupted protein--protein interaction precludes expression of the toxin reporter gene and, consequently, allows survival of the host cell. TOXSEL technology enables large-scale screening for drugs or small molecules capable of disrupting specific protein--protein interactions critical in processes such as cellular signalling, carcinogenesis, etc. The positive selection of molecules or mutations capable of interfering with specific protein--protein interactions permits the identification of amino acid residues or motifs critical in the protein--protein interactions and permits the design of drugs for therapeutic or diagnostic applications. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009209038-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03004643-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5917017-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010174049-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9169481-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0161346-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02072790-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03076668-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03076668-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004166538-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006019921-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003162733-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8048986-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0161346-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6841352-B2 |
priorityDate |
1995-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |