| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21069
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6459 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-71 |
| filingDate |
1994-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1998-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_819cf4966e158678bdf591c5da7d0959
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5b47a6c0d1eacc46fe9ad49ba024fd0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5d197bd8d2ba1bcd94b1395bac4bb96
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_521bb7541299db99ef0059932d0cf12a |
| publicationDate |
1998-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5728565-A |
| titleOfInvention |
Methods of preparing tissue plasminogen activator derivatives |
| abstract |
Tissue plasminogen activator (t-PA) derivatives are produced in useful quantities using recombinant DNA techniques. Specific derivatives include amino acid deletion derivatives and amino acid substitution derivatives. A deletion derivative lacking the N-terminal first 68 amino acids is specifically exemplified having requisite t-PA characteristics. The invention disclosed thus enables the production of t-PA derivatives via recombinant means. Methods, expression vehicles and various host cells useful in the production of said t-PA derivatives are also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008069857-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009297573-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006104969-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8969295-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6495322-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003096288-A1 |
| priorityDate |
1982-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |