| abstract |
PCT No. PCT/US92/09713 Sec. 371 Date Jul. 12, 1994 Sec. 102(e) Date Jul. 12, 1994 PCT Filed Nov. 6, 1992 PCT Pub. No. WO93/08842 PCT Pub. Date May 13, 1993The invention relates to methods and compositions for delivering drugs to the body by binding them to hemoglobin. This technique stabilizes the drug and extends its half-life in the body. The drug may be chemically coupled to or adsorbed on the hemoglobin chain(s). Therapeutics are preferably linked to an artificial hemoglobin via a cysteine located deep within a cleft in the hemoglobin molecule. |