| abstract |
The present invention provides a medicinal composition containing a heme-based therapeutic agent for treating cancer. The heme moiety can target cancer cells and the therapeutic moiety (ie, the active agent / therapeutic drug) can effectively kill the cancer cells. The heme-based therapeutic agent used in the present invention can be used to treat various cancers, such as pancreatic cancer, leukemia, head and neck cancer, colorectal cancer, lung cancer, breast cancer, liver cancer, nasopharyngeal cancer, esophageal cancer, prostate cancer, gastric cancer and Brain cancer. The composition can be used alone or in combination with other therapeutic agents such as chemotherapeutics to give synergistic effects on cancer treatment, inhibition of cancer metastasis, and / or reduction of recurrence. The heme-based 5FU-two dye conjugate and / or the heme-based 5FU-one dye conjugate claimed in the present invention can also be used for live cell imaging and diagnostic imaging. |