| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_152218feda4a2c0ca4e070ce869481ff |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-881 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-66 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 |
| filingDate |
1995-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1997-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b29b948bc80aa5de1f94d5f0a0ad19b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65731818f30677c70607665b8f18a991
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bf3fd53e030110810d7f882d8ef4495 |
| publicationDate |
1997-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5658796-A |
| titleOfInvention |
Optical resolution of alkyl chroman-2-carboxylates |
| abstract |
Described herein is a process for resolving a racemic (C>3) alkyl (R, S) chroman-2-carboxylate compound useful as intermediates in the synthesis of optically pure pharmaceutical compounds is disclosed. The process utilizes a microbial enzyme derived from Serratia marcescens to catalyze the enantioselective hydrolysis of the (C>3) alkyl (S)-chroman-2-carboxylate enantiomer of the racemic mixture to its corresponding carboxylic acid at a faster rate than the R-enantiomer. An enantiomerically pure S-configured carboxylic acid is thereby formed which can undergo acidic esterification to provide an optically pure (C>3) alkyl (S)-chroman-2-carboxylate intermediate for subsequent pharmaceutical synthesis. The nonhydrolyzed (C>3) alkyl (R)-chroman-2-carboxylate enantiomer can also be isolated to provide an optically pure pharmaceutical precursor. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7043069-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6060290-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7365095-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006258714-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008182891-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6303349-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011001063-A1 |
| priorityDate |
1995-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |