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filingDate 1992-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fb57b2c83c18a09a80094ad55840171
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publicationDate 1995-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5378627-A
titleOfInvention Process for preparing (2S,3R)-3-alkyl-phenylglycidic acid esters using lipase
abstract A process for preparing optically active 3-phenylglycidic acid esters comprising reacting a racemic trans-3-phenylglycidic acid with an alkanol in the presence of a hydrolase to esterify preferentially either (2S, 3R) isomer or (2R, 3S) isomer of said racemic compound and isolating and collecting the resulting optically active 3-phenylglycidic acid ester from the reaction mixture, whereby the optically active ester can be produced in a single step and in a highly pure form. The optically active 3-phenylglycidic acid esters are useful for the preparation of 1,5-benzothiazepine derivatives having pharmacological activities such as platelet aggregation inhibitory activity.
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