abstract |
10,11-Methanodibenzosuberane derivatives, i.e., the compounds of Formula I: ##STR1## wherein: A is --CH 2 --CH 2 --, --CH 2 --CHR a --CH 2 --, or --CH 2 --CHR a --CHR b --CH 2 --, where one of R a or R b is H, OH, or lower acyloxy, and the other is H; n R 1 is H, F, Cl or Br; n R 2 is H, F, Cl or Br; and n R 3 is heteroaryl or phenyl optionally substuted with F, Cl, Br, CF 3 , CN, NO 2 or OCHF 2 ; n and the pharmaceutically acceptable salts thereof, are useful chemosensitizing agents, e.g., for cancer chemotherapy, particularly for treating multidrug resistance. |