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filingDate 1995-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1997-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18b54852946c50e560c615912749f8ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_971123d164981ef3e436f148fd8adfb2
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publicationDate 1997-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5631394-A
titleOfInvention Pharmaceutically active ceramide-related compounds
abstract This invention provides a compound having the formula R1-Y1-CHZ1-CH(NY2Y3)-CH2-Z2, wherein: R1 is a straight-chained alkyl, alkenyl or alkynyl group having from 8 to 19 carbon atoms in the aliphatic chain; Y1 is -CH=CH-, -C 3BOND C- or -CH(OH)CH(OH)-; Z1 is OH or a conversion-inhibiting group; Z2 is a conversion-inhibiting group; Y2 is H, a phenyl group, an alkyl-substituted phenyl group having from 1 to about 6 carbons in the alkyl chain, or an alkyl chain having from 1 to 6 carbons; Y3 is H or a group having the formula -C(O)R2 or -S(O)2R2; R2 is a straight-chained alkyl, alkenyl or alkynyl group having from 1 to 23 carbon atoms in the chain; and when Z2 is an amino, R2 is an aliphatic chain having from 1 to 9 or from 19 to 23 carbon atoms in the aliphatic chain.
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