| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06139 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078 |
| filingDate |
1996-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1997-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_767c94ee590fcadc766aa9acdebdbcea |
| publicationDate |
1997-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5624936-A |
| titleOfInvention |
Inhibitors of farnesyl-protein transferase |
| abstract |
The present invention comprises analogs of the CA1A2X motif of the protein Ras that is modified by farnesylation in vivo. These CA1A2X analogs inhibit the farnesyl-protein transferase and the farnesylation of certain proteins. Furthermore, these CA1A2X analogs differ from those previously described as inhibitors of farnesyl-protein transferase in that they do not have a thiol moiety. The lack of the thiol offers unique advantages in terms of improved pharmacokinetic behavior in animals, prevention of thiol-dependent chemical reactions, such as rapid autoxidation and disulfide formation with endogenous thiols, and reduced systemic toxicity. The compounds of the instant invention also incorporate a cyclic amine moiety in the A2 position of the motif. Further contained in this invention are chemotherapeutic compositions containing these farnesyl transferase inhibitors and methods for their production. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9403774-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0031238-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10208021-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9394276-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9079929-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9777001-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9315519-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10081623-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5981487-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9453018-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10906886-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10000466-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9447110-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9000172-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6455281-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9944625-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9918096-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9920034-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6271197-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11053247-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6277564-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6683057-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10336754-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9738655-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9108951-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9192607-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9725435-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6696280-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6727082-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0031238-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10273236-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6610532-B2 |
| priorityDate |
1995-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |