| abstract |
The invention provides novel compounds of the formula: <IMAGE> (I) wherein R1 and R2, which can be the same or different are H or OH, R3 is <IMAGE> wherein R4 and R5, which can be the same or different are H or an alkyl group of 1 to 4 carbon atoms, and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof, which compounds include metabolites of toremifene and exhibit valuable pharmacological properties as oestrogenic, anti-oestrogenic, and progestanic agents. |