abstract |
The present invention provides novel benzothiophene compounds of formula I <IMAGE> I wherein R is -H, -OH, -O(C1-C4 alkyl), -O-CO-(C1-C6 alkyl), -O-CO-Ar in which Ar is optionally substituted phenyl, or -O-SO2-(C4-C6 alkyl); R1 is -H, -OH, -O(C1-C4 alkyl), -O-CO-(C1-C6 alkyl), -O-CO-Ar in which Ar is optionally substituted phenyl, -O-SO2-(C4-C6 alkyl) chloro or bromo; R2 is -H or -OH; n is 2 or 3; and R3 and R4 each are independently C114 C4 alkyl, or combine to form 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, or 1-hexamethyleneimino; or a pharmaceutically acceptable salt thereof, for inhibiting restenosis. |