| abstract |
The subject invention relates to compounds having the structure: <IMAGE> wherein (a) X is selected from hydroxy, C1 to about C2 alkanoxy, thiol, C1 to about C2 alkanylthiol, and halo; (b) R and R' are each independently selected from C1 to about C3 straight or branched alkanyl, and C3 to about C4 cyclic alkanyl; or R and R' are bonded together to form a C3 to about C6 cyclic alkanyl ring, or a C3 to about C5 cyclic heteroalkanyl ring having one oxygen or sulfur atom in the ring, the heteroatom not being bonded to the carbon to which X is bonded; and R and R', or the ring formed by them when bonded together, are each, independently, unsubstituted or monosubstituted with a substituent selected from halo, hydroxy, thiol, C1 to about C2 alkanoxy, and C1 to about C2 alkanylthiol. The subject invention also relates to the pharmaceutical compositions comprising the above compounds, and methods of treating inflammation using the compounds. |