| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_087bed7abab91ae0f927879f9fe8b273 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-81 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-81 |
| filingDate |
1991-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1995-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_006e42a4412b10dc27b78306e3393b94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a7d0f03ecbefd0c9df31921cbe955bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7b068243b2876c513c3174b3da10fef |
| publicationDate |
1995-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5416008-A |
| titleOfInvention |
Cross-regulation of gene expression in recombinant cells |
| abstract |
Recombinant cells providing for the controlled expression of product proteins by way of cross-regulation between interacting operons. A structural gene for a product protein and a structural gene for a repressor of a second operon are included in a first operon. A protein encoded by a structural gene of the second operon is a repressor of the first operon. The second operon may reside on a plasmid or a chromosome of the host cell. The present invention provides for controlled expression of product protein over a range of copy numbers, as well as high transcription efficiency in the induced state. The invention includes methods for the controlled expression of product protein by recombinant cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003166879-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109311931-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101411788-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-768595-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19990010008-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2777292-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6485934-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6828140-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9953080-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6844169-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017177147-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6841376-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6737269-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003166191-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005058665-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0032748-A1 |
| priorityDate |
1991-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |