| abstract |
Compounds of formula (I): <IMAGE> (I) <IMAGE> A is a carbon-carbon bond or C1-C3 alkylene; B is imino group or C1-C2 alkylene; R1 is C1-C4 alkyl, C1-C4 alkoxy, heterocyclic or optionally substituted amino; R2 is optionally substituted phenyl or optionally substituted naphthyl; R3 is thiazolyl, isoxazolyl or imidazolyl; R4 is isopropyl or cyclohexyl; R5 and R6 are C1-C4 alkyl, or, together with the carbon atom to which they are attached, C3-C7 cycloalkyl; R7 is hydrogen, optionally substituted C1-C6 alkyl group; and R8 is hydrogen or C1-C4 alkyl. These compounds have renin-inhibitory and, hence, hypotensive activities. The invention also provides a method for the treatment or prophylaxis of hypertension induced by failures in the renin-angiotensin system. |