| abstract |
PCT No. PCT/US92/00443 Sec. 371 Date Jul. 1, 1993 Sec. 102(e) Date Jul. 1, 1993 PCT Filed Jan. 17, 1992 PCT Pub. No. WO92/13536 PCT Pub. Date Aug. 20, 1992.The present invention is novel compounds which are 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions. |