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filingDate 1993-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1994-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d96064a86b078bcd76bf018fb814bb40
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publicationDate 1994-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5316932-A
titleOfInvention Homogeneous denatured human 06-guanine alkyltransferase prepared by immunoaffinity chromatography using monoclonal antibody specific for enzyme
abstract A denatured human O6-guanine alkyltransferase is disclosed. The enzyme is prepared by a process which involves denaturing the enzyme, contacting the denatured enzyme with a monoclonal antibody specific for the denatured enzyme on a substrate to which the monoclonal antibody is bound to, so that the denatured enzyme and the monoclonal antibody form an immunocomplex and then, eluting the denatured enzyme from the substrate-bound monoclonal antibody so that the denatured human O6-guanine alkyltransferase is obtained. The enzyme can be used to develop probes for the Mer- phenotype and these probes in turn are contemplated for use in identifying drug resistant tumors in patients.
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priorityDate 1989-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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