| abstract |
A compound of the formula: <IMAGE> wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, -CH2OH or -OH; and G and D are independently selected from hydrogen, C1 to C10 alkyl, -OH, -CH2OH, -CH2OR20 wherein R20 is C1 to C6 alkyl, -CH2OC(O)R21 wherein R21 is C1 to C10 alkyl, -CH2OC(O)CH(R22)(NHR23) wherein R22 is the side chain of any of the naturally occurring amino acids and R23 is hydrogen or -C(O)CH(R24)(NH2) wherein a R24 is the side chain of any of the naturally occurring amino acids, -CH2SH, -CH2Cl, -CH2F, -CH2Br, -CH2I, -C(O)H, -CH2CN, -CH2N3, -CH2NR1R2, -CO2R1, -CH2CH2OH, -CH2CH2OR20 wherein R20 is as defined above, -CH2CH2OC(O)R21 wherein R21 is as defined above, -CH2CH2OC(O)CH(R22)(NHR23) wherein R22 and R23 are as defined above, -CH2CH2PO3H2, -CH2OPO3H2, -OCH2PO3H2 and -CH2CO2R3 wherein R1 and R2 are independently selected from hydrogen and C1 to C10 alkyl and R3 is hydrogen, C1 to C10 alkyl, carboxyalkyl or aminoalkyl; or a pharmaceutically acceptable salt thereof. |