http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4644001-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_359b45ab51dbd97bd513b984a50c5ef0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-545 |
| filingDate | 1984-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1987-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79443194157ea68bdef78db1ea5e01db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_feb9ba35ef88e0fd9111e7d71bd474c0 |
| publicationDate | 1987-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4644001-A |
| titleOfInvention | 3-Alkylxanthines, composition and methods for the treatment of chronic obstructive-airway disease and cardiac disease |
| abstract | 3-Alkylxanthines characterized by the formula n<CHEM>n wherein R<1> is n-propyl, n-butyl, isobutyl, n-pentyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, cyclopropyl, cyclobuty, cyclopentyl of cyclohexylmethyl, and R<2> is hydrogen or methyl, provided that R<2> is methyl when R<1> is n-propyl, n-butyl or isobutyl, or a physiologically acceptable salt thereof, for example the compound 3-cyclopetnyl-3, 7-dihydro-1H-purine-2, 6-dione, have activity against chronic obstructive airway disease or cardiac disease. These compounds are produced by several methods, exemplified by the following one: reacting a compound of the formula n<CHEM>n with a compound of the formulan R<2>-Xn wherein R<1> and R<2> have the definition given above and X is -COOH, -CONH2 or -OC-O-CO-R2 and, if necessary, submitting the obtained product to dehydration. The starting compounds wherein R<1> is n-pentyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, cyclopropyl, cyclobutyl, cyclopentyl or cylohexylmethyl are not previously described in teh literature They are prepared by reacting a compound of the formula R<1>NHCONH2 with cyanoacetic acid, cyclising the produced 1-cyanoycetyl-3-R<1>urea with alkali, nitrosing the so produced 1-R<1>-6-aminouracil with HNO2 and reducing the so produced 1-R<1>-5-nitroso-6-aminouracil with H2//PtO2. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4988703-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5342840-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5246931-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0366059-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5321029-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5153352-A |
| priorityDate | 1978-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 231.