http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5212172-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef2e9f5ce8630d9b282043b8d060caff |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65515 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-655 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-60 |
| filingDate | 1991-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1993-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e66ca16e35ee6edc638a465261bd69e1 |
| publicationDate | 1993-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5212172-A |
| titleOfInvention | 4-(1-hydroxy-2-substituted amino)ethyl-5-hydroxy-2(5H)-furanones as anti-inflammatory agents |
| abstract | Compounds of the formula <IMAGE> Formula 1 where R1 is H or alkyl of 1 to 20 carbons, CO-R1*, CO-O-R1*, CO-NH-R1*, or PO(OR1*)2, PO(OR1*)R1* where R1* independently is H, alkyl of 1 to 20 carbons, phenyl, or substituted phenyl; R2 is H or alkyl of 1 to 20 carbons; X is H, R3, CO-R3, CO-O-R3, CO-NH-R3, CO-N-(R3)2, PO(OR3)2, PO(OR3)R3, and R3 independently is H, phenyl, substituted phenyl, alkyl of 1 to 20 carbons or is alkyl of 1 to 20 carbons substituted with a hydroxyl, alkoxy, substituted amino, thioalkoxy or with a COR3* group where R3* is H, lower alkyl, OH, OR3**, NH2, NHR3** or N(R3**)2 group where R3** independently is H or lower alkyl, with the proviso that when X is CO-O-R3 or is CO-NH-R3 then R3 is not hydrogen; Y is H, R4, CO-R4, CO-O-R4, CO-N-piperazinyl, CO-N-substituted N-piperazinyl, CO-N-morpholinyl, CO-N-substitutetd N-morpholinyl, CO-NH-R4, or CO-N(R4)2, PO(OR4)2, PO(OR4)R4, SO2OR4, or SO2R4, where R4 independently is H, phenyl or substituted phenyl, or alkyl of 1 to 20 carbons, or is alkyl of 1 to 20 carbons substituted with a hydroxyl, alkoxy, substituted amino, thioalkoxy, with a COR4* or with a O-COR4*group where R4* is H, lower alkyl, OH, OR4**, NH2, NHR4** or N(R4**)2 group where R4** is lower alkyl with the proviso that when Y is CO-O-R4 then R4 is not hydrogen, are disclosed. The compounds have anti-inflammatory activity in mammals, including humans. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006116718-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010095940-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5541221-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3827747-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5451686-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2392258-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4218718-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5387606-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008036682-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2147679-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012044761-A1 |
| priorityDate | 1990-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 209.