| abstract |
Renin inhibiting compounds of the formula: <IMAGE> containing two alpha -amino acids or a single alpha -amino acid wherein R1 is a phosphorus containing moiety, W is oxygen or NR3 and A is a moiety selected from those of the formula: <IMAGE> wherein Z is O, S, SO, SO2 and p is an integer from 1 to 2; and, when W is oxygen, A may also be a moiety of the formula <IMAGE> and analogs thereof which compounds inhibit the substrate-cleaving action of renin, pharmaceutical compositions containing these compounds, processes for producing the compounds and methods of treating hypertension which employ the novel renin inhibitors. |