abstract |
Novel compounds of formula (I) and salts, solvates and hydrates thereof, processes for their preparation and their use in the treatment of conditions in which degradation of connective tissue and other proteinaceous components of the body occurs:n in which, R is hydrogen, C₁₋₆ alkyl or optionally substituted benzyl; R₁ is hydrogen or C₁₋₆ alkyl; R₂ is C₃₋₆ alkyl; R₃ is hydrogen, alkyl, -CH₂-Z where Z is optionally substituted phenyl or heteroaryl, or R₃ is a groupn where R₇ is hydrogen, alkyl or -CH₂-Ph where Ph is optionally substituted phenyl and R₈ is hydrogen or alkyl; and R₄ is -CH₂-(CH₂) n OR₅ or -CH₂-(CH₂) n OCOR₆ or -CH(R₉)COR₁₀, where n is an integer from 1 to 6; R₅, R₆ and R₉ are hydrogen or C₁₋₆ alkyl; and R₁₀ is hydroxy or -O-C₁₆ alkyl or -NR₅R₆ (where R₅ and R₆ may be linked to form a heterocyclic ring; or R₃ and R₄ are joined together as -(CH₂) m - where m is an integer from 4 to 12. |