| abstract |
Anti-inflammatory 4-substituted 2-furanones are made from intermediates having the formulas: <IMAGE> Formula 1 in which R1, R2 and R3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons; X is H, OH, NH2, I or Br; R4 is H, alkyl of 1-20 carbons, phenyl[C1-C20alkyl], naphthyl[C1-C20alkyl], CH2OH, CH2NH2, CH2CH2OH, CH2-CHO, CH2-COOH or CH2-COOR5, and R5 is alkyl of 1 to 6 carbons, with the proviso that when X is hydrogen then R4 is selected from the group consisting of CH2OH, CH2NH2, CH2CH2OH, CH2-CHO, or CH2-COOR5; <IMAGE> Formula 2 in which R1, R2 and R3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl or 1 to 6 carbons, and R5 is alkyl or 1 to 6 carbons; <IMAGE> in which R1, R2 and R3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons, and R6 is phenyl, or alkyl of 1 to 6 carbons, and <IMAGE> in which R1, R2 and R3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons. |