| abstract |
Compounds of the formula <IMAGE> where X is O or S; R1 is lower alkyl having 1 to 6 carbons; R2 is H, lower alkyl having 1 to 6 carbons; or OR2* where R2* is lower alkyl having 1 to 6 carbons; Y is O, S or NH; and R3 is H, lower alkyl having 1 to six carbons, or C(O)R3* where R3* is lower alkyl having 1 to 5 carbons, with the proviso that the YR3 group is not disposed in the ortho position on the benzene nucleus relative to the 2-amino group of the oxazoline or thiazoline heterocycle, are active in maintaining or reducing intraocular pressure in the mammalian eye, and are active as vasoconstrictors and capable of reducing or controlling intraocular bleeding of the mammalian eye. |