http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4975438-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-16 |
| filingDate | 1988-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1990-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c33b51eccaefe784f4fe3e6b71bd665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6064c8dd00b458cb90b5ec9e7344be26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dfe4087b2bb890a7a43681864f14ce9 |
| publicationDate | 1990-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4975438-A |
| titleOfInvention | Pentadieneamide compounds which have useful activity of treating a disease characterized by an excess of platelet activating factor |
| abstract | Compounds of the formula <IMAGE> I Y is O or S, *A is paraphenylene or *-(CH2)n-(X)m-(CH2)r-, X is O, S or -CH=CH-, n or r, independently, are integers from 0 to 3, s is an integer from 0 to 1, m is an integer from 0 to 1, provided that when m is 1, n+s must be at least 2, R1 and R2, independently, are hydrogen, lower alkyl, cycloalkyl, lower alkenyl, Het, Aryl, R3, R4 and R8, independently, are hydrogen, lower alkyl, aryl, R5 and R6, independently, are hydrogen or lower alkyl, R7 is hydrogen, lower alkyl, cycloalkyl, Het-lower alkyl or aryl, Het is a monocyclic 5- or 6-membered hetero aromatic or a bicyclic heteroaromatic radical containing one or two hetero atoms selected from nitrogen, oxygen and sulfur, which radical may be substituted by lower alkyl, halogen or aryl, and the asterisk denotes the point of attachment, and when R6 and R7 are different, their enantiomers and racemic mixtures thereof, when R1 and R2 are different, their geometric isomers, and pharmaceutically acceptable acid addition salts thereof, are described. The compounds of formula I exhibit activity as platelet activating factor (PAF) antagonists and are, therefore, useful in disease states characterized by excess platelet activating factor or for the prevention and treatment of cardiovascular diseases, pulmonary diseases, immunological disorders, inflammatory diseases, dermatological disorders, shock or transplant rejection. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8653131-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010048483-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8962549-B2 |
| priorityDate | 1987-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 3760.