| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cbff64022f95c237c0bd3ec8656ca |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-862
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-866
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-864
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S424-809
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S424-805 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-4266
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-4283
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6873 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
1983-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1988-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_067a2146f4008f99d8be75dc102b4c60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21d35bab9f2bc3f472041e2a002acbee |
| publicationDate |
1988-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4792447-A |
| titleOfInvention |
Anti-immunoglobulin toxin conjugates useful in the treatment of B cell tumors |
| abstract |
Highly specific antibodies directed against immunoglobulin determinants coupled to one or more toxin molecules provide antibody-toxin conjugates which are useful in selectively inhibiting the growth of target immunoglobulin generating cells. The antibody-toxin conjugate consists of an antibody specific for a selected immunoglobulin determinant including isotypic, allotypic or idiotypic variable determinants, coupled to one or more toxin molecules. Anti-idiotype toxin conjugates are provided which have specificity which distinguishes B cell tumor cells from normal B cells. Also disclosed is an antibody-toxin conjugate consisting of anti-IgD A chain. The antibody-toxin conjugate is used as a cell or tumor specific cytotoxic agent directed selectively against those cells expressing the corresponding immunoglobulin to which the antibody portion has specificity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5690935-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8114619-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6632440-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5620686-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004048784-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7452971-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8852603-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7018633-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2005216575-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008102027-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006216283-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0538267-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011152174-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8034791-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7727538-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007010447-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7923221-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003143193-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6693083-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004242523-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006100135-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1614600-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010054328-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003124742-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003082685-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015140019-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008249019-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2001006954-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005112062-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6042829-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6960652-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6887469-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6251866-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2872877-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0538267-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7052702-B1 |
| priorityDate |
1981-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |