| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd5ab29f0d041de89e4d36e513f62edf |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-33 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-02 |
| filingDate |
2008-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66e78cfaaa2ff7fdcdea502c82503875
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fcd9065cd225c8f4ccc8c22fa28c578 |
| publicationDate |
2008-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008249019-A1 |
| titleOfInvention |
Treatment of mucus hypersecretion |
| abstract |
A polypeptide and a nucleic acid encoding the polypeptide are described. The polypeptide includes a cytotoxic toxin, a targeting domain that selectively binds to a target cell that is a mucus-secreting cell and a translocating domain that translocates the cytotoxic toxin into the target cell. A nucleic acid encoding the polypeptide is also described. Also described is a pharmaceutical composition for topical administration to a patient suffering from mucus hypersecretion which includes the polypeptide and a formulation component selected from the group consisting of an excipient, an adjuvant and a propellant. Methods of treating hypersecretion of mucus, chronic obstructive pulmonary disease (COPD) or asthma are also described. These methods include administering to a patient in need thereof a therapeutically effective amount of the polypeptide. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011047135-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011047135-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10736948-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9006395-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7674470-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009274708-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11419923-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016095910-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011028691-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8012479-B2 |
| priorityDate |
1998-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |