| abstract |
The present invention is concerned with the preparation of lysosomotropic detergent agents and pharmaceutical composition useful in the treatment of cancer. These compounds are amine derivatives having a pK of 3.5 of the general structure <IMAGE> in which R1 is C8-30 alkyl, C8-30-alkenyl, substituted C4-30 alkyl or substituted C4-30-alkenyl; R2 is hydrogen or C1-4 alkyl and Y is an electron withdrawing group, to control the pK, selected from trifluoroethyl, and difluoroethyl. |