| abstract |
Hydrazinopyridiazine derivatives of the formula: <IMAGE> +TR <IMAGE> wherein A is alkylene, wherein either R1 is hydrogen and R2 is hydrogen, alkoxycarbonyl or aralkoxycarbonyl, or R1 and R2 together form alkylidene, aralkylidene, alkoxycarbonylalkylidene or aralkoxycarbonylalkylidene, wherein either R3 and R4, which may be the same or different, each is hydrogen, halogen, hydroxy, amino, nitro, trifluoromethyl, carbamoyl, cyano, alkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkylthio, cycloalkoxy, alkenyloxy, alkynyloxy, alkanoyl, aryl, aryloxy or dialkylamino, or R3 and R4 together with the adjacent benzene ring form indanyl, 5,6,7,8-tetrahydronaphthyl, 5-oxo-5,6,7,8-tetrahydronaphthyl, indenyl, 5,8-dihydronaphthyl or naphthyl, wherein either R5 and R6, which may be the same or different, each is hydrogen or alkyl, or R5 and R6 together with the adjacent pyridazine ring form phthalazinyl, and wherein X is oxygen or -NHCO-, -NHCO-A1- or -NHCO-A1-O- wherein A1 is alkylene, acid-addition salts thereof, processes for their manufacture and pharmaceutical composition containing them. The compounds possess antihypertensive activity. |