| abstract |
Cis-exo 7-oxabicycloheptane substituted amide prostaglandin analogs are provided having the structural formula <IMAGE> wherein A is -CH=CH- or -CH2-CH2-; n is 1 to 5; R is CO2H, CO2alkyl, CO2alkali metal, CO2polyhydroxyamine salt, -CH2OH, <IMAGE> wherein R2 and R3 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R2 and R3 being other than hydroxy and lower alkoxy; X is O, NH, CH=CH, or -(CH2)x wherein x is 0 or 1; and R1 is lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, amino, alkylamino, arylamino, arylthio or alkylthio. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease. |