| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-24 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-06 |
| filingDate |
1984-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1985-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc5097cbbd2741625a6e82905cb3cea8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_807f4b006c1d726f256471fe4f5a3511 |
| publicationDate |
1985-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4533675-A |
| titleOfInvention |
Carbamates of colchicine for treatment of gout |
| abstract |
The present invention consists of derivatives of colchicine and thiocolchicine which are carbamates of the same and are illustrated by the formula below: <IMAGE> where either X1 or X2 is a hydroxy group and the other a lower alkoxy group and R1 can be H or an alkyl, R2 an alkyl, alkenyl or aryl which may be substituted and R3 is either OCH3 or SCH3; alkyl and alkoxy=C1-C6; aryl=monoaryl. These compounds are not only new but have exhibited antitumor activity binding to tubulin protein and tests against P388 lymphocytic leukemia and also active against gouty arthritis. Further, they are far less toxic than colchicine. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9458101-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6399093-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004113281-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-303386-B6
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0493064-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6627774-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7622612-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008280987-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0168597-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5220002-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7119229-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012225912-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2678440-C1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100761577-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5231107-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5204479-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007021427-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004204494-A1 |
| priorityDate |
1984-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |