| abstract |
The present invention provides new three-layered pharmaceutical film preparations which comprise one drug-storing middle layer composed of one or more (a) polyvinylpyrrolidone, (b) hydroxypropyl cellulose, (c) plasticizers and (d) organic acids, containing prostaglandin analogues, and two release-controlling layers on both sides of the said middle layer, composed of one or more (a) hydroxypropyl cellulose and (b) plasticizers, containing or not containing prostaglandin analogues, and which may release the drug at the desired concentration lastingly for an extended period of time, with great high biological availability, and can make this release "zero-order release", and further have improved the stability of the drug contained therein, and in which the form of the preparation is not retained at the administered site after administration. |