http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4435329-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14effe3850d2129f863b969dac4f1db8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-20 |
| filingDate | 1981-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1984-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52743e1d5d6d0cec5bdc5701e8a274f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f432ad9d25d1ab9c12cbb5402e3d369b |
| publicationDate | 1984-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4435329-A |
| titleOfInvention | Substituted N-(ω-aroylpropionyl) derivatives of α-amino acids and esters thereof |
| abstract | Novel compounds are described having the formula <IMAGE> wherein Z is <IMAGE> R1 is hydrogen or a C1-C4 lower alkyl; R2 is hydrogen, a C1-C4 lower alkyl, hydroxy-R8-, lower alkyl-R8-, mercapto-R8-, cyclohexyl, cyclopentyl, phenyl, phenyl-R8-, indolyl-R8-, carboxy-R8-, amino-R8- or carbamoyl-R8-, wherein R8- is a divalent C1-C6 straight chain parafinic moiety; R3 is hydrogen or C1-C4 lower alkyl; R4 is hydrogen, lower alkanoyl, benzoyl or phenyl-substituted-lower alkanoyl; R5 is hydrogen or a C1-C4 lower alkyl; R1, R2 and R5 excluding tertiary butyl; ARYL is 1-naphthyl, 2-naphthyl, 4-chloro-1-naphthyl, 4-methoxy-1-naphthyl, 5,6,7,8-tetrahydro-1-naphthyl, 5,6,7,8-tetrahydro-2-naphthyl, 4-biphenylyl, 5-indanyl, 4-indanyl, phenyl, or substituted phenyl moieties having the formula <IMAGE> wherein R6 is fluoro, chloro, bromo, trifluoromethyl, cyano, phenoxy, halophenoxy, phenylthio, halophenylthio, a C1-C4 lower alkyl or a C1-C4 lower alkoxy, and R7 is chloro, fluoro, bromo, a C1-C4 lower alkyl or a C1-C4 lower alkoxy; and where m is an integer of zero, one or two; including individual optically active isomers; racemic mixtures thereof; non-toxic pharmacologically-acceptable salts of the foregoing; and mixtures of the foregoing. Processes of preparing such compounds are also described. Such compounds are useful in ameliorating hypertension in mammals. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006063294-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0236734-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0329013-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4889869-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4931591-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0329013-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008194681-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0024251-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0236734-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5994539-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006063294-A3 |
| priorityDate | 1981-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 680.