| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b4beef0c137d9094e6918ee382be22f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C53-136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C275-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C239-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C53-136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 |
| filingDate |
1978-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1979-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a14dd0efa089e5af9a58740ad11f523
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_053515e97f04c1991dd3f9fc22576dc9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2931f4c16ed24131a76de71e900c4030 |
| publicationDate |
1979-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4177280-A |
| titleOfInvention |
Bicyclo[3.1.0]hexyl-substituted carbonylaminophenoxy cardiovascular agents |
| abstract |
1-Alkylamino-3-(4-[(endobicyclo[3.1.0]hex-6-yl)alkylure ido]-1-phenoxy)-2-propanol and substituted derivatives thereof; 1-alkylamino-3-(4-[(endobicyclo[3.1.0]hex-6-yl)-alkylcarbonylamino]-1-phenoxy)-2-propanol and substituted derivatives thereof; and 1-alkylamino-3-(4-[(endobicyclo-[3.1.0]hex-6-yl)alkoxycarbonylamino]-1-phenoxy)-2-propanol and substituted derivatives thereof as well as methods for preparing such compounds are disclosed. 5-(4-[(Endobicyclo[3.1.0]hex-6-yl)alkylureido]-1-phenoxy) methyl-3-alkyl-2-optionally substituted oxazolidine and derivatives thereof; 5-(4-[(endobicyclo[3.1.0]hex-6-yl alkylcarbonylamino]-1-phenoxy)methyl-3-alkyl-2-optionally substituted oxazolidine and derivatives thereof; and 5-(4-[(endobicyclo[3.1.0]hex-6-yl)alkoxycarbonylamino]-1-phenoxy)methyl-3-alkyl-2-optionally substituted oxazolidine and derivatives thereof and methods for preparing these compounds are also disclosed. These compounds exhibit cardiovascular activity and are useful in the treatment of abnormal heart conditions as well as hypertension in mammals. The bicyclo-2-propanols are prepared by treatment of the corresponding 1,2-epoxy-3-(4-[(endobicyclo[3.1.0]hex-6-yl)alkylureido, alkylcarbonylamino or alkoxycarbonylamino-1-phenoxypropane, with the desired alkylamine or by base or acid hydrolysis of the corresponding 5-(4-[(endobicyclo[3.1.0]-hex-6-yl)alkylureido, alkylcarbonylamino or alkoxycarbonylamino]-1-phenoxy)-methyloxazolidine. The lattercompounds are prepared from the corresponding 1-alkylamino-3-(4-[(endobicyclo[3.1.0]-hex-6-yl)alkylureido, alkylcarbonylamino or alkoxycarbonylamino]-1-phenoxy)-2-propanol by treatment with an aldehyde having the desired optional substituent. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110191709-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010095940-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012044761-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11173145-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2147679-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2392258-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11046649-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006116718-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3827747-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008036682-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4218718-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3570832-A4 |
| priorityDate |
1978-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |