http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4151297-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b4beef0c137d9094e6918ee382be22f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-22 |
| filingDate | 1977-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1979-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a14dd0efa089e5af9a58740ad11f523 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2931f4c16ed24131a76de71e900c4030 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b600ba9c7379b70ac0173723aef838bb |
| publicationDate | 1979-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4151297-A |
| titleOfInvention | Bicyclo [3.1.0] hexyl-substituted ethylamino carbonyl phenoxy cardiovascular agents |
| abstract | 1-Alkylamino-3-(3- or 4-[2-(endobicyclo[3.1.0]-hex-6-yl)ethylaminocarbonyl]-1-phenoxy)-2-pro panol and substituted derivatives thereof and methods for preparing such compounds are disclosed. 5-(3- Or 4-[2-(endobicyclo[3.1.0]hex-6-yl)ethylaminocarbonyl]-phenoxy)methyl 3-alkyl-2-optionally substituted oxazolidine and derivatives thereof, and methods for preparing such compounds are also disclosed. These compounds exhibit cardiovascular acitivity and are useful in the treatment of abnormal heart condition as well as hypertension in mammals. The former compounds are prepared by treatment of the corresponding 1,2-epoxy-3-(3- or 4-[2-(endobicyclo[3.1.0]hex-6-yl)-ethylaminocarbonyl]phenoxy)propane with the desired alkylamine or by base or acid hydrolysis of the corresponding 5-(3- or 4-[2-(endobicyclo[3.1.0]hex-6-yl)-ethylaminocarbonyl)-3-alkyl oxazolidine. The latter compounds are prepared from the corresponding 1-alkylamino-3-(3- or 4-[2-(endobicyclo[3.1.0]hex-6-yl)ethylaminocarbonyl]-1-phenoxy)-2-prop anol by treatment with an aldehyde having the desired optional substituent or by treating a 3- or 4-(2-(endobicyclo[3.1.0]hex-6-yl)ethylaminocarbonyl)-optionally substituted phenol with a 5-tosyloxy or mesyloxymethyl 3-alkyl)-methyloxazolidine-2-optionally substituted oxazolidine. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2147679-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012044761-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010095940-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3827747-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4218718-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006116718-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2392258-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008036682-A2 |
| priorityDate | 1977-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 227.