http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4064259-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b4beef0c137d9094e6918ee382be22f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-56 |
| filingDate | 1976-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1977-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a14dd0efa089e5af9a58740ad11f523 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b600ba9c7379b70ac0173723aef838bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53ac1578792af1200fcf803bd9ef4cda |
| publicationDate | 1977-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4064259-A |
| titleOfInvention | Thiazole cardiovascular agents |
| abstract | 1-Alkylamino-3-(5-alkenylaminocarbonylthiazol-2-yloxy)-2-propanol; 5-(5-alkenylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidine and/or 2-substituted oxazolidine derivatives thereof, and methods of making such compounds. The compounds exhibit cardiovascular activity and are useful in the treatment of abnormal heart conditions in mammals. The compounds are also useful in the treatment of hypertension in mammals. The 5-(5-alkenylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidines and derivatives are also intermediates for the 1-alkylamino-3-(5-alkenylaminocarbonylthiazol-2-yloxy)-2-propanols. The 1-alkylamino-3-(5-alkenylaminocarbonylthiazol-2-yloxy)-2-propanols can be prepared by base or acid hydrolysis of the corresponding 5-(5-alkenylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidine or derivative; or by treatment of the corresponding 3-(5-alkenylaminocarbonylthiazol-2-yloxy)-2,3-epoxypropane with the desired alkylamine. Similarly the 5-(5-alkenylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidine or derivative can be prepared from the corresponding 1-alkylamino-3-(5-alkenylaminocarbonylthiazol-2-yloxy)-2-propanols via treatment with an aldehyde or ketone. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2147679-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012044761-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2392258-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010095940-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006116718-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3827747-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4218718-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008036682-A2 |
| priorityDate | 1976-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 496.