http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4001421-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b4beef0c137d9094e6918ee382be22f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-425 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-425 |
| filingDate | 1975-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1977-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40218263edd7d327e8acfc4cea8c53d5 |
| publicationDate | 1977-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4001421-A |
| titleOfInvention | Thiazole cardiovascular agents |
| abstract | 1-Amino-3-(4- or 5-substituted thiazol-2-oxy)-2-propanol and/or substituted amino derivatives thereof; 3-(4- or 5-substituted thiazol-2-oxy)-1,2-epoxypropane and 5-(4- or 5-substituted thiazol-2-oxymethylene)-oxazolidine and/or N- and/or 2-substituted oxazolidine derivatives thereof, are methods of making such compounds. The compounds are characterized by an aminocarbonyl or carbonylamino type substituent at the 5- or 4-position on the thiazole ring. The above 1-amino-3-(4- or 5-substituted thiazol-2-oxy)-2-propanol and derivatives exhibit cardiovascular activity and are useful in the treatment of abnormal heart conditions in mammals. The 3-(4- or 5-substituted thiazol-2-oxy)-1,2-epoxypropanes are useful as intermediates for the aforementioned cardiovascular agents. The 5-(4- or 5-substituted thiazol-2-oxymethylene)-oxazolidine and derivatives are intermediates for the aforementioned cardiovascular agents and further exhibit cardiovascular activity and thus are useful in the treatment of abnormal heart conditions in mammals. The 1-amino-3-(4-or 5-substituted thiazol-2-oxy)-2-propanol and derivatives can be prepared by base or acid hydrolysis of the corresponding 5-(4- or 5-aminocarbonylthiazol-2-oxymethylene)-oxazolidine or derivative; or by treatment of the corresponding 3-(4- or 5-substituted thiazol-2-oxy)-2,3-epoxypropane or derivative with the desired amine or amine derivative. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010095940-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3827747-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012044761-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006116718-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008036682-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4218718-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2147679-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9961055-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2392258-A1 |
| priorityDate | 1971-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1532.