| abstract |
Quinine, quinidine and analogs thereof, are prepared by reacting a 4-quinolyllithium compound with a 4,5-erythro-5-ethyl(or vinyl)-quinuclidine-2 Epsilon -carboxaldehyde or the corresponding quinuclidine-2-carboxylic acid alkyl ester. Also described, inter alia, is the preparation of a 4,5-erythro-5ethyl(or vinyl)-quinuclidine-2 Epsilon -carboxaldehyde, and a 4,5-erythro-5-ethyl(or vinyl)-quinuclidine-2 Epsilon -carboxylic acid and esters thereof. The end products are useful as antimalarial and antiarrhythmic agents. |