| abstract |
Heterocyclic esters of 1,4-ethano-1,2,3,4-tetrahydro-5H(1)benzopyrano(3,4-b)pyridines and 1,4-ethano-1,2,3,4,13,14hexahydro-5H-(1)benzopyrano(3,4-b)pyridines. The esters have the formulas WHEREIN R2 is lower alkyl, R3 is an alkyl having one to twenty carbon atoms, a cycloalkyl-lower alkyl or a phenyl-lower alkyl, Y is a straight or branched chain alkylene having one to eight carbon atoms, and R4 is a group of the formula wherein a is an integer from 1 to 4, b is an integer from 1 to 4 and X is CH2O, S or N-R5 with R5 being hydrogen or lower alkyl, and R6 is hydrogen or a lower alkyl group bonded to a carbon in the ring. The compounds have pharmacological activity, including analgesic, anti-convulsive and tranquilizing activity in animals. The compounds can be administered in pharmaceutical composition form. |