| abstract |
N-(1,1,1-trisubstituted)-methylazoles are produced by reacting thionyl-imidazole with a substituted carbinol of the formula: wherein A is aliphatic, cycloaliphatic, aromatic or heteroaromatic, B is aliphatic, cycloaliphatic, aromatic or a 5or 6-membered heteroaromatic ring having 1 to 3 N-heteroatoms or 1 or 2 N-heteroatoms plus an oxygen or sulphur heteroatom and D is aliphatic, cycloaliphatic, aromatic, alkoxycarbonyl, alkoxycarbonylalkyl, aryloxycarbonyl or a 5- or 6-membered heteroaromatic ring having 1 to 3 N-heteroatoms or 1 or 2 Nheteroatoms plus an oxygen or sulphur heteroatom and related carbinols. The reactants are in 1:1 molar ratio and the reaction is carried out in dry inert solvents at a temperature of -20* C. to +150* C. |