| abstract |
An N-(1-Z-4(or 3)-piperidyl)acylanilide, having antidiarrheal utility, is prepared by reacting an N-(4(or 3)piperidyl)acylanilide with a Z-halide or by reacting a 4(or 3)(Q-anilino)-1-Z-piperidine with an acyl halide or anhydride, where Z is lower-alkyl, 3-cyano-3,3-diphenylpropyl or 2cyanoethyl, acyl is propionyl, lactyl, dichloroacetyl or carbethoxy, and Q is hydrogen or (halo)n where halo is fluoro or chloro and n is 1 or 2. Also included are corresponding N-(4(or 3)-pyridyl)-, N-(3-quinuclidinyl)-, and N-(8-Z-3-nortropanyl)acylanilides. |