abstract |
2B, 16B-DIAMINO-ANDROSTANE COMPOUNDS OXYGENATED IN THE 3- AND 17-POSITIONS, WHEREIN THE AMINO GROUPS MAY BE DIALKYLAMINO AND HETEROCYCLIC AMINO GROUPS, AND THEIR ACID ADDITION SALTS AND QUATERNARY AMMONIUM SALTS, ARE PREPARED BY REACTING A 16A, 17A-OXIDO-, OR A 16-KETO-STEROID WITH AN AMINE AT ELEVATED TEMPERATURE AND PRESSURE, FOLLOWED BY REDUCTION TO THE CORRESPONDING 17B-HYDROXY DERIVATIVE. THE COMPOUNDS OF THE INVENTION ARE HIGHLY ACTIVE NEUROMUSCULAR BLOCKING AGENTS AND HAVE A STRONG INFLUENCE ON THE AUTONOMIC NERVOUS SYSTEM. |