http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019177716-A1

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filingDate 2019-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b51672127cdd2721e4d540867de81f73
publicationDate 2019-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2019177716-A1
titleOfInvention Ligand-guided-selection method for screening antigen-specific ligands
abstract A Ligand-guided-Selection (LIGS) method for identifying highly specific aptamers against a predetermined antigen of a target is provided. LIGS uses a stronger and highly specific bivalent binder (e.g. an antibody) interacting with its cognate antigen to displace specific aptamers from an enriched SELEX pool. Elution of the displaced aptamers provides aptamers that are specific to the predetermined antigen.
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priorityDate 2015-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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