| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afa80f22a2246c6e8ab232c4d5a7ab83 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G2650-32 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-334
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-332
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-333
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-33324
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L101-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G83-002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-33306 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-333
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-332
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-334
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 |
| filingDate |
2016-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dae6b82cf2020c05c7852a2384ecb39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0fcd3793d856eb88aa769ed39b2329e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3ac13bfb077791232b66d83b0e42ba3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a10c0757a78cd49f93e62f750421c8d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_862787df385d9e1e43c6f89734ca7d12 |
| publicationDate |
2018-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2018214561-A1 |
| titleOfInvention |
Eight-arm polyethylene glycol derivative, production method therefor, and modifiedbio-relatedsubstancethereof |
| abstract |
Disclosed are an eight-arm polyethylene glycol (PEG) derivative (formula I), production method therefor and modified bio-related substance thereby. Wherein, one tetravalent group U together with four trivalent groups E c form a highly symmetrical octavalent group CORE 0 ; L c connects the octavalent group to eight PEG chains having polydispersity or monodispersity and having n 1 to n 8 as the degree of polymerization thereof; the terminal of one PEG chain is connected to at least one functional group F (k≥1); said PEG chain and F therebetween can be directly connected (g=0) or be indirectly connected via a linking group L 0 to a terminal end-branching group G (g=1); the latter provides more reactive sites for binding more drug molecules and increases the drug loading. The eight-arm polyethylene glycol derivative has a centrosymmetric or approximately centrosymmetric structure, and leads to more precise control of the molecular weight in large-scale production and much narrower distribution of molecular weight for products. The modified bio-related substance thereby has a more uniform and controllable performance. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022192619-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10660969-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115671405-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11642414-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112851928-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111494391-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023051801-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11324827-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113201132-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112851842-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11253603-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11613607-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022170012-A1 |
| priorityDate |
2015-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |